Treatment of PANDAS and PANS: a systematic review

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Treatment of PANDAS and PANS: a systematic review

Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) are a subtype of acute-onset obsessive-compulsive disorder (OCD) thought to be caused by an autoimmune response to group A streptococcal infection. Based on this proposed pathophysiology, alternative treatments for acute-onset OCD have been introduced, including antibiotics and immunomodulatory int...

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OBJECTIVE Sudden onset clinically significant eating restrictions are a defining feature of the clinical presentation of some of the cases of pediatric acute-onset neuropsychiatric syndrome (PANS). Restrictions in food intake are typically fueled by contamination fears; fears of choking, vomiting, or swallowing; and/or sensory issues, such as texture, taste, or olfactory concerns. However, body...

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PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections) syndrome is a disorder that presents itself before adolescence with an abrupt onset of obsessive-compulsive disorder symptoms and/or tics. This disorder is related to Group A streptococcal (GAS) infection with neurological findings, such as motor hyperactivity and choreiform movements. The progress...

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Depression is a common symptom and a major public health problem in the elderly. Despite its prevalence and seriousness, depressive disorder in older people remains under-treated. The optimal treatment of depression in later life is crucial, and requires appreciation of several age-related factors such as comorbidity, polypharmacy, altered drug kinetics, variable treatment response and increase...

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ژورنال

عنوان ژورنال: Neuroscience & Biobehavioral Reviews

سال: 2018

ISSN: 0149-7634

DOI: 10.1016/j.neubiorev.2018.01.001